Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16260

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.45, p 0.230). This receipt's hash covers every field on it, plus the hash of receipt 16259, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16260
    31 Oct 2026, 13:12 UTC

    TESC

    dopamine neurons, braak

    predictionTESC in dopamine neurons tracks Braak Lewy-body stage

    registered8c117d2479a48018

    discovery-0.45 p=0.230 n=9

    replication+0.03 p=0.929 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.45, p 0.230)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7395a845a1fb16a71b0b3009…
    follows d3b7235ec46a…

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The swarm's case

receipt 16260: TESC in dopamine neurons, braak

power
full sample -0.22 (p 0.389, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.21 (p 0.398, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.29 (p 0.239, n 18). could be the mix.
skeptic
leave-one-out range -0.34 to -0.12, sign flips 0; without severely affected donors -0.22 (p 0.389, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TESC in dopamine neurons.

case closed: nothing better to follow up.