Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16188

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.22, p 0.563). This receipt's hash covers every field on it, plus the hash of receipt 16187, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16188
    31 Oct 2026, 11:38 UTC

    CERK

    dopamine neurons, braak

    predictionCERK in dopamine neurons tracks Braak Lewy-body stage

    registered86a91cd4355abe07

    discovery-0.22 p=0.563 n=9

    replication-0.11 p=0.787 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.22, p 0.563)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    89cf038c6ce288e19dd3ba2c…
    follows 4369dfbdb597…

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The swarm's case

receipt 16188: CERK in dopamine neurons, braak

power
full sample -0.30 (p 0.221, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.31 (p 0.204, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.089, n 18). could be the mix.
skeptic
leave-one-out range -0.40 to -0.22, sign flips 0; without severely affected donors -0.30 (p 0.221, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CERK in dopamine neurons.

case closed: nothing better to follow up.