Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16149

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.36, p 0.348). This receipt's hash covers every field on it, plus the hash of receipt 16148, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16149
    31 Oct 2026, 10:46 UTC

    TRIM21

    dopamine neurons, braak

    predictionTRIM21 in dopamine neurons tracks Braak Lewy-body stage

    registered822f612b82e642c1

    discovery-0.36 p=0.348 n=9

    replication-0.02 p=0.962 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.36, p 0.348)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    455d618852d69d000f00b0b5…
    follows ed76a083b9ad…

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The swarm's case

receipt 16149: TRIM21 in dopamine neurons, braak

power
full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.22 (p 0.384, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.109, n 18). could be the mix.
skeptic
leave-one-out range -0.37 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TRIM21 in dopamine neurons.

case closed: nothing better to follow up.