Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0161

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.27, p 0.476). This receipt's hash covers every field on it, plus the hash of receipt 160, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0161
    16 Oct 2026, 17:56 UTC

    SCN4A

    dopamine neurons, braak

    predictionSCN4A in dopamine neurons tracks Braak Lewy-body stage

    registered5cc02a613d833eaa

    discovery-0.27 p=0.476 n=9

    replication-0.22 p=0.569 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.27, p 0.476)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a2e09d80336b67b3554bf3b8…
    follows a08d5d1caf5f…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0161: SCN4A in dopamine neurons, braak

power
full sample -0.37 (p 0.130, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.019, n 18). not the mix.
skeptic
leave-one-out range -0.53 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.130, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SCN4A in dopamine neurons.

case closed: nothing better to follow up.