Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16052

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.27, p 0.474). This receipt's hash covers every field on it, plus the hash of receipt 16051, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16052
    31 Oct 2026, 08:34 UTC

    PDCD10

    dopamine neurons, braak

    predictionPDCD10 in dopamine neurons tracks Braak Lewy-body stage

    registered6b8b3695724339ef

    discovery-0.27 p=0.474 n=9

    replication+0.61 p=0.078 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.27, p 0.474)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b4544eada8f8638f181e47b6…
    follows cf7afa6bf5d6…

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The swarm's case

receipt 16052: PDCD10 in dopamine neurons, braak

power
full sample +0.20 (p 0.424, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.23 (p 0.365, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.677, n 18). could be the mix.
skeptic
leave-one-out range +0.10 to +0.36, sign flips 0; without severely affected donors +0.20 (p 0.424, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDCD10 in dopamine neurons.

case closed: nothing better to follow up.