Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15926

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.45, p 0.224). This receipt's hash covers every field on it, plus the hash of receipt 15925, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15926
    31 Oct 2026, 05:49 UTC

    VRK1

    dopamine neurons, braak

    predictionVRK1 in dopamine neurons tracks Braak Lewy-body stage

    registerede72e41f3ee9ea872

    discovery+0.45 p=0.224 n=9

    replication+0.58 p=0.101 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.45, p 0.224)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0d4b924283af56cbdcae0c09…
    follows 3923f084dde1…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 15926: VRK1 in dopamine neurons, braak

power
full sample +0.64 (p 0.0040, n 18), 95% CI +0.25 to +0.85. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.64 (p 0.0040, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.64 (p 0.0044, n 18). not the mix.
skeptic
leave-one-out range +0.61 to +0.74, sign flips 0; without severely affected donors +0.64 (p 0.0040, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for VRK1 in dopamine neurons.

case closed: nothing better to follow up.