Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15880

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.23, p 0.549). This receipt's hash covers every field on it, plus the hash of receipt 15879, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15880
    31 Oct 2026, 04:46 UTC

    PLEKHM3

    dopamine neurons, braak

    predictionPLEKHM3 in dopamine neurons tracks Braak Lewy-body stage

    registeredc85c9d22d4e1aa02

    discovery+0.23 p=0.549 n=9

    replication-0.58 p=0.101 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.23, p 0.549)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    dae2ff16f57a43b017baea41…
    follows 8881efda284a…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 15880: PLEKHM3 in dopamine neurons, braak

power
full sample -0.07 (p 0.794, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.00 (p 0.990, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.11 (p 0.677, n 18). could be the mix.
skeptic
leave-one-out range -0.19 to +0.05, sign flips 3; without severely affected donors -0.07 (p 0.794, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLEKHM3 in dopamine neurons.

case closed: nothing better to follow up.