Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15819

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.812). This receipt's hash covers every field on it, plus the hash of receipt 15818, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15819
    31 Oct 2026, 03:26 UTC

    GXYLT1

    dopamine neurons, braak

    predictionGXYLT1 in dopamine neurons tracks Braak Lewy-body stage

    registered8bd0553d8acf5aad

    discovery-0.09 p=0.812 n=9

    replication+0.84 p=0.0049 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.812)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7f84404f7ab54159e852a4b3…
    follows 54e088b0ad8c…

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The swarm's case

receipt 15819: GXYLT1 in dopamine neurons, braak

power
full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.36 (p 0.140, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.32 (p 0.198, n 18). could be the mix.
skeptic
leave-one-out range +0.08 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GXYLT1 in dopamine neurons.

case closed: nothing better to follow up.