Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15713

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.10, p 0.807). This receipt's hash covers every field on it, plus the hash of receipt 15712, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15713
    31 Oct 2026, 01:52 UTC

    RPL8

    dopamine neurons, braak

    predictionRPL8 in dopamine neurons tracks Braak Lewy-body stage

    registeredeb889004acd7caba

    discovery-0.10 p=0.807 n=9

    replication+0.26 p=0.502 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.10, p 0.807)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a227f948e6c3e1ab1a9cc502…
    follows 0ae03a415a99…

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The swarm's case

receipt 15713: RPL8 in dopamine neurons, braak

power
full sample +0.06 (p 0.827, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.06 (p 0.827, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.12 (p 0.633, n 18). could be the mix.
skeptic
leave-one-out range -0.06 to +0.18, sign flips 5; without severely affected donors +0.06 (p 0.827, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RPL8 in dopamine neurons.

case closed: nothing better to follow up.