Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15659

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.62, p 0.073). This receipt's hash covers every field on it, plus the hash of receipt 15658, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15659
    31 Oct 2026, 00:40 UTC

    GMNC

    dopamine neurons, braak

    predictionGMNC in dopamine neurons tracks Braak Lewy-body stage

    registered6342ef9ddd5700d5

    discovery+0.62 p=0.073 n=9

    replication-0.21 p=0.591 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.62, p 0.073)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6dbb2a9b8f88696a620d9fd1…
    follows 31fb32067476…

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The swarm's case

receipt 15659: GMNC in dopamine neurons, braak

power
full sample +0.04 (p 0.867, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.03 (p 0.922, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.754, n 18). could be the mix.
skeptic
leave-one-out range -0.10 to +0.15, sign flips 4; without severely affected donors +0.04 (p 0.867, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GMNC in dopamine neurons.

case closed: nothing better to follow up.