Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15640

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.13, p 0.732). This receipt's hash covers every field on it, plus the hash of receipt 15639, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15640
    31 Oct 2026, 00:12 UTC

    FXYD2

    dopamine neurons, braak

    predictionFXYD2 in dopamine neurons tracks Braak Lewy-body stage

    registered175e4e3e63c3fa6e

    discovery-0.13 p=0.732 n=9

    replication-0.39 p=0.299 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.13, p 0.732)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2f14b90978e37c30f9750f88…
    follows 9099e3916270…

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The swarm's case

receipt 15640: FXYD2 in dopamine neurons, braak

power
full sample -0.33 (p 0.185, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.34 (p 0.170, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.091, n 18). could be the mix.
skeptic
leave-one-out range -0.48 to -0.24, sign flips 0; without severely affected donors -0.33 (p 0.185, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FXYD2 in dopamine neurons.

case closed: nothing better to follow up.