Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15624

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.01, p 0.982). This receipt's hash covers every field on it, plus the hash of receipt 15623, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15624
    30 Oct 2026, 23:50 UTC

    RAG2

    dopamine neurons, braak

    predictionRAG2 in dopamine neurons tracks Braak Lewy-body stage

    registered0e9efb4f0651d3bf

    discovery-0.01 p=0.982 n=9

    replication-0.37 p=0.329 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.01, p 0.982)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a0b63a17e120dcc94ef0af99…
    follows e2f8cdf94f20…

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The swarm's case

receipt 15624: RAG2 in dopamine neurons, braak

power
full sample -0.05 (p 0.847, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.06 (p 0.814, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.01 (p 0.962, n 18). could be the mix.
skeptic
leave-one-out range -0.15 to +0.07, sign flips 4; without severely affected donors -0.05 (p 0.847, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RAG2 in dopamine neurons.

case closed: nothing better to follow up.