Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15545

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.58, p 0.101). This receipt's hash covers every field on it, plus the hash of receipt 15544, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15545
    30 Oct 2026, 22:03 UTC

    OSR1

    dopamine neurons, braak

    predictionOSR1 in dopamine neurons tracks Braak Lewy-body stage

    registered7ffbb7363113f402

    discovery-0.58 p=0.101 n=9

    replication-0.45 p=0.230 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.58, p 0.101)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    9d766bbf0aaeee0dfd3b55be…
    follows 84366d39ecb0…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 15545: OSR1 in dopamine neurons, braak

power
full sample -0.40 (p 0.103, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.37 (p 0.135, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.018, n 18). not the mix.
skeptic
leave-one-out range -0.56 to -0.32, sign flips 0; without severely affected donors -0.40 (p 0.103, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OSR1 in dopamine neurons.

case closed: nothing better to follow up.