Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15494

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.62, p 0.073). This receipt's hash covers every field on it, plus the hash of receipt 15493, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15494
    30 Oct 2026, 20:57 UTC

    FRY

    dopamine neurons, braak

    predictionFRY in dopamine neurons tracks Braak Lewy-body stage

    registered63188446a1d23066

    discovery+0.62 p=0.073 n=9

    replication+0.11 p=0.785 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.62, p 0.073)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    653fe315f5ebc86269e8d4cc…
    follows 7beb0db4a1e3…

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The swarm's case

receipt 15494: FRY in dopamine neurons, braak

power
full sample +0.33 (p 0.182, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.34 (p 0.170, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.091, n 18). could be the mix.
skeptic
leave-one-out range +0.23 to +0.48, sign flips 0; without severely affected donors +0.33 (p 0.182, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FRY in dopamine neurons.

case closed: nothing better to follow up.