Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1545

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.17, p 0.663). This receipt's hash covers every field on it, plus the hash of receipt 1544, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1545
    18 Oct 2026, 01:19 UTC

    SLC18B1

    dopamine neurons, braak

    predictionSLC18B1 in dopamine neurons tracks Braak Lewy-body stage

    registered38f89e6d8b99df37

    discovery+0.17 p=0.663 n=9

    replication+0.05 p=0.894 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.17, p 0.663)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    528568ee3554dd7c86b6f4da…
    follows cc79a21df62f…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1545: SLC18B1 in dopamine neurons, braak

power
full sample +0.13 (p 0.615, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.13 (p 0.597, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.360, n 18). could be the mix.
skeptic
leave-one-out range -0.01 to +0.21, sign flips 2; without severely affected donors +0.13 (p 0.615, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC18B1 in dopamine neurons.

case closed: nothing better to follow up.