Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15448

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.12, p 0.749). This receipt's hash covers every field on it, plus the hash of receipt 15447, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15448
    30 Oct 2026, 19:54 UTC

    TP53BP2

    dopamine neurons, braak

    predictionTP53BP2 in dopamine neurons tracks Braak Lewy-body stage

    registeredbd69521a446a1b12

    discovery-0.12 p=0.749 n=9

    replication+0.42 p=0.266 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.12, p 0.749)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2bfa761c60c5ba330e25fc16…
    follows e8d9b416d767…

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The swarm's case

receipt 15448: TP53BP2 in dopamine neurons, braak

power
full sample +0.06 (p 0.814, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.06 (p 0.814, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
skeptic
leave-one-out range -0.04 to +0.18, sign flips 3; without severely affected donors +0.06 (p 0.814, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TP53BP2 in dopamine neurons.

case closed: nothing better to follow up.