Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15437

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.18, p 0.639). This receipt's hash covers every field on it, plus the hash of receipt 15436, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15437
    30 Oct 2026, 19:37 UTC

    SPCS3

    dopamine neurons, braak

    predictionSPCS3 in dopamine neurons tracks Braak Lewy-body stage

    registered6ddada74ea9ea179

    discovery-0.18 p=0.639 n=9

    replication-0.47 p=0.199 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.18, p 0.639)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5b4ec8ffaccd7d8bea86f697…
    follows 99c0085aed63…

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The swarm's case

receipt 15437: SPCS3 in dopamine neurons, braak

power
full sample -0.21 (p 0.403, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.26 (p 0.294, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.585, n 18). could be the mix.
skeptic
leave-one-out range -0.36 to -0.12, sign flips 0; without severely affected donors -0.21 (p 0.403, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SPCS3 in dopamine neurons.

case closed: nothing better to follow up.