Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15309

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.54, p 0.129). This receipt's hash covers every field on it, plus the hash of receipt 15308, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15309
    30 Oct 2026, 16:46 UTC

    CDC123

    dopamine neurons, braak

    predictionCDC123 in dopamine neurons tracks Braak Lewy-body stage

    registered6fa8d5a807d856d4

    discovery+0.54 p=0.129 n=9

    replication+0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.54, p 0.129)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    73b2780cc8d504b72529c26a…
    follows 43907aabf312…

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The swarm's case

receipt 15309: CDC123 in dopamine neurons, braak

power
full sample +0.33 (p 0.176, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.29 (p 0.243, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.37 (p 0.132, n 18). could be the mix.
skeptic
leave-one-out range +0.25 to +0.47, sign flips 0; without severely affected donors +0.33 (p 0.176, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CDC123 in dopamine neurons.

case closed: nothing better to follow up.