Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15240

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.09, p 0.820). This receipt's hash covers every field on it, plus the hash of receipt 15239, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15240
    30 Oct 2026, 15:13 UTC

    TMEM128

    dopamine neurons, braak

    predictionTMEM128 in dopamine neurons tracks Braak Lewy-body stage

    registeredae46716b61fb784b

    discovery+0.09 p=0.820 n=9

    replication+0.36 p=0.348 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.09, p 0.820)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a61ce57ceb008b15a21fbc0b…
    follows a63c78a0a588…

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The swarm's case

receipt 15240: TMEM128 in dopamine neurons, braak

power
full sample +0.30 (p 0.232, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.42 (p 0.086, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.42 (p 0.080, n 18). could be the mix.
skeptic
leave-one-out range +0.21 to +0.42, sign flips 0; without severely affected donors +0.30 (p 0.232, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TMEM128 in dopamine neurons.

case closed: nothing better to follow up.