Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15179

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.47, p 0.199). This receipt's hash covers every field on it, plus the hash of receipt 15178, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15179
    30 Oct 2026, 13:53 UTC

    FYCO1

    dopamine neurons, braak

    predictionFYCO1 in dopamine neurons tracks Braak Lewy-body stage

    registeredc96df4b84169e8cf

    discovery-0.47 p=0.199 n=9

    replication-0.30 p=0.430 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.47, p 0.199)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c372867f80d1eb452462bf5b…
    follows a140df219851…

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The swarm's case

receipt 15179: FYCO1 in dopamine neurons, braak

power
full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.39 (p 0.114, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.65 (p 0.0033, n 18). not the mix.
skeptic
leave-one-out range -0.50 to -0.32, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FYCO1 in dopamine neurons.

case closed: nothing better to follow up.