Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1504

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.02, p 0.964). This receipt's hash covers every field on it, plus the hash of receipt 1503, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1504
    18 Oct 2026, 00:21 UTC

    MRPS7

    dopamine neurons, braak

    predictionMRPS7 in dopamine neurons tracks Braak Lewy-body stage

    registeredda5e32c0a5604fd3

    discovery-0.02 p=0.964 n=9

    replication-0.05 p=0.907 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.02, p 0.964)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    054208200ab8974ed646d59a…
    follows 2db2d525e988…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1504: MRPS7 in dopamine neurons, braak

power
full sample -0.01 (p 0.956, n 18), 95% CI -0.48 to +0.46. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.03 (p 0.915, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.04 (p 0.881, n 18). could be the mix.
skeptic
leave-one-out range -0.15 to +0.14, sign flips 6; without severely affected donors -0.01 (p 0.956, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MRPS7 in dopamine neurons.

case closed: nothing better to follow up.