Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14887

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.17, p 0.670). This receipt's hash covers every field on it, plus the hash of receipt 14886, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14887
    30 Oct 2026, 06:02 UTC

    VAT1

    dopamine neurons, braak

    predictionVAT1 in dopamine neurons tracks Braak Lewy-body stage

    registeredb6cd07ac20d0ef5c

    discovery-0.17 p=0.670 n=9

    replication-0.22 p=0.576 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.17, p 0.670)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    e79b4b81dde527272727cca4…
    follows bc70d48c4cae…

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The swarm's case

receipt 14887: VAT1 in dopamine neurons, braak

power
full sample -0.18 (p 0.471, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.18 (p 0.471, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.787, n 18). could be the mix.
skeptic
leave-one-out range -0.35 to -0.09, sign flips 0; without severely affected donors -0.18 (p 0.471, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for VAT1 in dopamine neurons.

case closed: nothing better to follow up.