Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14699

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.25, p 0.523). This receipt's hash covers every field on it, plus the hash of receipt 14698, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14699
    30 Oct 2026, 02:25 UTC

    KLF6

    dopamine neurons, braak

    predictionKLF6 in dopamine neurons tracks Braak Lewy-body stage

    registeredd2c453cda6053354

    discovery-0.25 p=0.523 n=9

    replication+0.21 p=0.591 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.25, p 0.523)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7b934df70e82d4b455bba4ae…
    follows f54f4c8a1c61…

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The swarm's case

receipt 14699: KLF6 in dopamine neurons, braak

power
full sample +0.07 (p 0.787, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.03 (p 0.894, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.04 (p 0.874, n 18). could be the mix.
skeptic
leave-one-out range -0.01 to +0.23, sign flips 2; without severely affected donors +0.07 (p 0.787, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KLF6 in dopamine neurons.

case closed: nothing better to follow up.