Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14674

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.637). This receipt's hash covers every field on it, plus the hash of receipt 14673, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14674
    30 Oct 2026, 01:52 UTC

    SORCS1

    dopamine neurons, braak

    predictionSORCS1 in dopamine neurons tracks Braak Lewy-body stage

    registered74c02eba6c4f3f5a

    discovery+0.18 p=0.637 n=9

    replication+0.22 p=0.565 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.637)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0ca7aa7581c4cf9c3431c31e…
    follows 5cea7cd32d84…

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The swarm's case

receipt 14674: SORCS1 in dopamine neurons, braak

power
full sample +0.25 (p 0.315, n 18), 95% CI -0.24 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.21 (p 0.413, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.27 (p 0.273, n 18). could be the mix.
skeptic
leave-one-out range +0.15 to +0.41, sign flips 0; without severely affected donors +0.25 (p 0.315, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SORCS1 in dopamine neurons.

case closed: nothing better to follow up.