Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14658

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.28, p 0.461). This receipt's hash covers every field on it, plus the hash of receipt 14657, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14658
    30 Oct 2026, 01:30 UTC

    FBXL16

    dopamine neurons, braak

    predictionFBXL16 in dopamine neurons tracks Braak Lewy-body stage

    registeredf23dc51b0956249e

    discovery-0.28 p=0.461 n=9

    replication-0.24 p=0.535 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.28, p 0.461)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d364eec11f50369e46abf4d3…
    follows fefda6cc94ee…

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The swarm's case

receipt 14658: FBXL16 in dopamine neurons, braak

power
full sample -0.19 (p 0.444, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.26 (p 0.302, n 18). could be the mix.
skeptic
leave-one-out range -0.30 to -0.08, sign flips 0; without severely affected donors -0.19 (p 0.444, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FBXL16 in dopamine neurons.

case closed: nothing better to follow up.