Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14562

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.651). This receipt's hash covers every field on it, plus the hash of receipt 14561, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14562
    29 Oct 2026, 23:19 UTC

    HTN1

    dopamine neurons, braak

    predictionHTN1 in dopamine neurons tracks Braak Lewy-body stage

    registered763f233159aca43d

    discovery+0.18 p=0.651 n=9

    replication-0.05 p=0.893 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.651)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    33523c495b000a2dd0058068…
    follows b855f1c560d9…

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The swarm's case

receipt 14562: HTN1 in dopamine neurons, braak

power
full sample +0.26 (p 0.289, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.36 (p 0.148, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.067, n 18). could be the mix.
skeptic
leave-one-out range +0.18 to +0.42, sign flips 0; without severely affected donors +0.26 (p 0.289, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HTN1 in dopamine neurons.

case closed: nothing better to follow up.