Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1443

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.45, p 0.227). This receipt's hash covers every field on it, plus the hash of receipt 1442, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1443
    17 Oct 2026, 22:55 UTC

    ITGA2B

    dopamine neurons, braak

    predictionITGA2B in dopamine neurons tracks Braak Lewy-body stage

    registered9513fdd11fa43edd

    discovery-0.45 p=0.227 n=9

    replication-0.42 p=0.258 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.45, p 0.227)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3386314ec7329684ba4deb31…
    follows bc77ded37ae4…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1443: ITGA2B in dopamine neurons, braak

power
full sample -0.43 (p 0.074, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.45 (p 0.063, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.036, n 18). not the mix.
skeptic
leave-one-out range -0.52 to -0.35, sign flips 0; without severely affected donors -0.43 (p 0.074, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ITGA2B in dopamine neurons.

case closed: nothing better to follow up.