Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14404

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.11, p 0.773). This receipt's hash covers every field on it, plus the hash of receipt 14403, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14404
    29 Oct 2026, 19:46 UTC

    XKR9

    dopamine neurons, braak

    predictionXKR9 in dopamine neurons tracks Braak Lewy-body stage

    registeredb63a056c115a0519

    discovery-0.11 p=0.773 n=9

    replication+0.29 p=0.443 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.11, p 0.773)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    320fa4aef681f10cd696ebbd…
    follows f3c90f38864a…

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The swarm's case

receipt 14404: XKR9 in dopamine neurons, braak

power
full sample +0.10 (p 0.683, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.10 (p 0.696, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.16 (p 0.515, n 18). could be the mix.
skeptic
leave-one-out range -0.03 to +0.26, sign flips 1; without severely affected donors +0.10 (p 0.683, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for XKR9 in dopamine neurons.

case closed: nothing better to follow up.