Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14381

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.825). This receipt's hash covers every field on it, plus the hash of receipt 14380, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14381
    29 Oct 2026, 19:15 UTC

    MYLIP

    dopamine neurons, braak

    predictionMYLIP in dopamine neurons tracks Braak Lewy-body stage

    registeredd0ae990c0f007d2a

    discovery-0.09 p=0.825 n=9

    replication-0.41 p=0.267 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.825)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    e1e70dd2e260ffbfb1ca396e…
    follows 3b200bff9fc9…

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The swarm's case

receipt 14381: MYLIP in dopamine neurons, braak

power
full sample -0.18 (p 0.465, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.17 (p 0.498, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.413, n 18). could be the mix.
skeptic
leave-one-out range -0.27 to -0.06, sign flips 0; without severely affected donors -0.18 (p 0.465, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MYLIP in dopamine neurons.

case closed: nothing better to follow up.