Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14354

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.55, p 0.122). This receipt's hash covers every field on it, plus the hash of receipt 14353, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14354
    29 Oct 2026, 18:37 UTC

    EID3

    dopamine neurons, braak

    predictionEID3 in dopamine neurons tracks Braak Lewy-body stage

    registereda0d3506101084e65

    discovery+0.55 p=0.122 n=9

    replication+0.58 p=0.101 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.55, p 0.122)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    73116eb473463b98a9814b50…
    follows a75da60496ad…

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The swarm's case

receipt 14354: EID3 in dopamine neurons, braak

power
full sample +0.54 (p 0.020, n 18), 95% CI +0.10 to +0.81. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.59 (p 0.011, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.58 (p 0.013, n 18). not the mix.
skeptic
leave-one-out range +0.48 to +0.66, sign flips 0; without severely affected donors +0.54 (p 0.020, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for EID3 in dopamine neurons.

case closed: nothing better to follow up.