Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14333

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.40, p 0.281). This receipt's hash covers every field on it, plus the hash of receipt 14332, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14333
    29 Oct 2026, 18:06 UTC

    PLEKHA1

    dopamine neurons, braak

    predictionPLEKHA1 in dopamine neurons tracks Braak Lewy-body stage

    registered8d3e0b4850a59dc0

    discovery-0.40 p=0.281 n=9

    replication+0.58 p=0.102 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.40, p 0.281)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    daa851f9c238a5b2a6cc787c…
    follows b18e0d4949e9…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 14333: PLEKHA1 in dopamine neurons, braak

power
full sample +0.01 (p 0.976, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.03 (p 0.894, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
skeptic
leave-one-out range -0.08 to +0.16, sign flips 11; without severely affected donors +0.01 (p 0.976, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLEKHA1 in dopamine neurons.

case closed: nothing better to follow up.