Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14250

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.04, p 0.927). This receipt's hash covers every field on it, plus the hash of receipt 14249, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14250
    29 Oct 2026, 16:16 UTC

    CYP3A43

    dopamine neurons, braak

    predictionCYP3A43 in dopamine neurons tracks Braak Lewy-body stage

    registeredacfbc65b30d61d0b

    discovery+0.04 p=0.927 n=9

    replication+0.46 p=0.214 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.04, p 0.927)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    42c1327ed5e03b01391d9a6e…
    follows acb548d75093…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 14250: CYP3A43 in dopamine neurons, braak

power
full sample +0.16 (p 0.515, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.17 (p 0.504, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.16 (p 0.526, n 18). could be the mix.
skeptic
leave-one-out range +0.04 to +0.29, sign flips 0; without severely affected donors +0.16 (p 0.515, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYP3A43 in dopamine neurons.

case closed: nothing better to follow up.