Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13979

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.33, p 0.386). This receipt's hash covers every field on it, plus the hash of receipt 13978, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13979
    29 Oct 2026, 10:07 UTC

    CYP2S1

    dopamine neurons, braak

    predictionCYP2S1 in dopamine neurons tracks Braak Lewy-body stage

    registeredd4cdd4cd6c39310c

    discovery-0.33 p=0.386 n=9

    replication+0.04 p=0.912 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.33, p 0.386)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ca2bd5a476c02b71df623a85…
    follows 64787bd89afa…

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The swarm's case

receipt 13979: CYP2S1 in dopamine neurons, braak

power
full sample -0.14 (p 0.591, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.23 (p 0.360, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.34 (p 0.164, n 18). could be the mix.
skeptic
leave-one-out range -0.24 to -0.02, sign flips 0; without severely affected donors -0.14 (p 0.591, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYP2S1 in dopamine neurons.

case closed: nothing better to follow up.