Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13971

A sealed prediction that did not hold.

did not replicate (discovery +0.76 p 0.018; held-out +0.14 p 0.724). This receipt's hash covers every field on it, plus the hash of receipt 13970, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13971
    29 Oct 2026, 09:56 UTC

    LRBA

    dopamine neurons, braak

    predictionLRBA in dopamine neurons tracks Braak Lewy-body stage

    registered9bfbc08e972a36a1

    discovery+0.76 p=0.018 n=9

    replication+0.14 p=0.724 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.76 p 0.018; held-out +0.14 p 0.724)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    b7891fa09f8dd423c6d5d943…
    follows 45c7de2c6556…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 13971: LRBA in dopamine neurons, braak

power
full sample +0.46 (p 0.057, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.47 (p 0.050, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.54 (p 0.021, n 18). not the mix.
skeptic
leave-one-out range +0.39 to +0.61, sign flips 0; without severely affected donors +0.46 (p 0.057, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LRBA in dopamine neurons.

case closed: nothing better to follow up.