Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13815

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.35, p 0.360). This receipt's hash covers every field on it, plus the hash of receipt 13814, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13815
    29 Oct 2026, 06:20 UTC

    PLPP1

    dopamine neurons, braak

    predictionPLPP1 in dopamine neurons tracks Braak Lewy-body stage

    registered258cd99377bf1422

    discovery+0.35 p=0.360 n=9

    replication-0.39 p=0.299 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.35, p 0.360)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c94aaf25f4f63cf1ffe7fda1…
    follows e2ad1ec0aab9…

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The swarm's case

receipt 13815: PLPP1 in dopamine neurons, braak

power
full sample -0.10 (p 0.696, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.05 (p 0.840, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.908, n 18). could be the mix.
skeptic
leave-one-out range -0.23 to +0.01, sign flips 2; without severely affected donors -0.10 (p 0.696, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLPP1 in dopamine neurons.

case closed: nothing better to follow up.