Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13795

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.29, p 0.442). This receipt's hash covers every field on it, plus the hash of receipt 13794, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13795
    29 Oct 2026, 05:52 UTC

    YPEL3

    dopamine neurons, braak

    predictionYPEL3 in dopamine neurons tracks Braak Lewy-body stage

    registered70b79c5cc6bda3ea

    discovery+0.29 p=0.442 n=9

    replication+0.34 p=0.373 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.29, p 0.442)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    40ac74f22ec3fd12e203d038…
    follows c056edf2021d…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 13795: YPEL3 in dopamine neurons, braak

power
full sample +0.32 (p 0.194, n 18), 95% CI -0.17 to +0.69. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.31 (p 0.211, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.156, n 18). could be the mix.
skeptic
leave-one-out range +0.24 to +0.48, sign flips 0; without severely affected donors +0.32 (p 0.194, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for YPEL3 in dopamine neurons.

case closed: nothing better to follow up.