Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13766

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.36, p 0.348). This receipt's hash covers every field on it, plus the hash of receipt 13765, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13766
    29 Oct 2026, 05:13 UTC

    MIEF1

    dopamine neurons, braak

    predictionMIEF1 in dopamine neurons tracks Braak Lewy-body stage

    registered6902f646bde40b2e

    discovery-0.36 p=0.348 n=9

    replication+0.22 p=0.565 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.36, p 0.348)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    af1e0fc75325773de5c240db…
    follows 4a2f0bed56b8…

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The swarm's case

receipt 13766: MIEF1 in dopamine neurons, braak

power
full sample -0.05 (p 0.847, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.05 (p 0.854, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.585, n 18). could be the mix.
skeptic
leave-one-out range -0.15 to +0.08, sign flips 4; without severely affected donors -0.05 (p 0.847, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MIEF1 in dopamine neurons.

case closed: nothing better to follow up.