Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13717

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.27, p 0.476). This receipt's hash covers every field on it, plus the hash of receipt 13716, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13717
    29 Oct 2026, 04:04 UTC

    JRKL

    dopamine neurons, braak

    predictionJRKL in dopamine neurons tracks Braak Lewy-body stage

    registered1a8c147f95738f6f

    discovery-0.27 p=0.476 n=9

    replication-0.28 p=0.473 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.27, p 0.476)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    bd24575010775d6f93172350…
    follows 16de4f785604…

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The swarm's case

receipt 13717: JRKL in dopamine neurons, braak

power
full sample +0.13 (p 0.603, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.07 (p 0.794, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic
leave-one-out range +0.03 to +0.27, sign flips 0; without severely affected donors +0.13 (p 0.603, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for JRKL in dopamine neurons.

case closed: nothing better to follow up.