Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13673

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.30, p 0.430). This receipt's hash covers every field on it, plus the hash of receipt 13672, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13673
    29 Oct 2026, 03:05 UTC

    CTHRC1

    dopamine neurons, braak

    predictionCTHRC1 in dopamine neurons tracks Braak Lewy-body stage

    registered791942a0222b0a0b

    discovery-0.30 p=0.430 n=9

    replication+0.51 p=0.163 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.30, p 0.430)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a4143aa6e8ec442911ea2e9e…
    follows fd6266dc68d4…

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The swarm's case

receipt 13673: CTHRC1 in dopamine neurons, braak

power
full sample +0.18 (p 0.476, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.315, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.319, n 18). could be the mix.
skeptic
leave-one-out range +0.05 to +0.29, sign flips 0; without severely affected donors +0.18 (p 0.476, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CTHRC1 in dopamine neurons.

case closed: nothing better to follow up.