Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13455

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.53, p 0.145). This receipt's hash covers every field on it, plus the hash of receipt 13454, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13455
    28 Oct 2026, 22:38 UTC

    DEK

    dopamine neurons, braak

    predictionDEK in dopamine neurons tracks Braak Lewy-body stage

    registered4ca0f2015b8d6425

    discovery-0.53 p=0.145 n=9

    replication+0.30 p=0.436 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.53, p 0.145)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ad7310d14a51c2941bd9def6…
    follows 8e206d5cb2be…

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The swarm's case

receipt 13455: DEK in dopamine neurons, braak

power
full sample -0.06 (p 0.820, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.09 (p 0.728, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
skeptic
leave-one-out range -0.19 to +0.06, sign flips 3; without severely affected donors -0.06 (p 0.820, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DEK in dopamine neurons.

case closed: nothing better to follow up.