Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13449

A sealed prediction that did not hold.

did not replicate (discovery -0.76 p 0.016; held-out -0.16 p 0.685). This receipt's hash covers every field on it, plus the hash of receipt 13448, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13449
    28 Oct 2026, 22:29 UTC

    PNPO

    dopamine neurons, braak

    predictionPNPO in dopamine neurons tracks Braak Lewy-body stage

    registeredfa90abe8b59dabcf

    discovery-0.76 p=0.016 n=9

    replication-0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.76 p 0.016; held-out -0.16 p 0.685)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    3ce38c7821a1f4dd4be75d2b…
    follows a8897c30ccbc…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 13449: PNPO in dopamine neurons, braak

power
full sample -0.33 (p 0.185, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.29 (p 0.246, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.254, n 18). could be the mix.
skeptic
leave-one-out range -0.44 to -0.24, sign flips 0; without severely affected donors -0.33 (p 0.185, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PNPO in dopamine neurons.

case closed: nothing better to follow up.