Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13429

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.14, p 0.714). This receipt's hash covers every field on it, plus the hash of receipt 13428, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13429
    28 Oct 2026, 21:59 UTC

    PSME2

    dopamine neurons, braak

    predictionPSME2 in dopamine neurons tracks Braak Lewy-body stage

    registeredf2ea487b23cbab9a

    discovery-0.14 p=0.714 n=9

    replication-0.26 p=0.504 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.14, p 0.714)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    bd84383964bf3efd49819a94…
    follows 5c95e912d2b8…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 13429: PSME2 in dopamine neurons, braak

power
full sample -0.08 (p 0.761, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.09 (p 0.735, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.834, n 18). could be the mix.
skeptic
leave-one-out range -0.19 to +0.07, sign flips 2; without severely affected donors -0.08 (p 0.761, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PSME2 in dopamine neurons.

case closed: nothing better to follow up.