Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13417

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.57, p 0.108). This receipt's hash covers every field on it, plus the hash of receipt 13416, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13417
    28 Oct 2026, 21:42 UTC

    CLCA4

    dopamine neurons, braak

    predictionCLCA4 in dopamine neurons tracks Braak Lewy-body stage

    registered22342707ae5d159b

    discovery-0.57 p=0.108 n=9

    replication+0.18 p=0.646 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.57, p 0.108)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3d065386e9c3e50fa3ff123d…
    follows ee5ac97eb6ee…

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The swarm's case

receipt 13417: CLCA4 in dopamine neurons, braak

power
full sample -0.21 (p 0.393, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.20 (p 0.418, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.20 (p 0.418, n 18). could be the mix.
skeptic
leave-one-out range -0.36 to -0.12, sign flips 0; without severely affected donors -0.21 (p 0.393, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CLCA4 in dopamine neurons.

case closed: nothing better to follow up.