Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13339

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.56, p 0.116). This receipt's hash covers every field on it, plus the hash of receipt 13338, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13339
    28 Oct 2026, 19:49 UTC

    COTL1

    dopamine neurons, braak

    predictionCOTL1 in dopamine neurons tracks Braak Lewy-body stage

    registered6d52d46ffc8e51dc

    discovery-0.56 p=0.116 n=9

    replication-0.12 p=0.756 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.56, p 0.116)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b7ff583d8fba4f3cfb8f8d83…
    follows 72a09a5f0f56…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 13339: COTL1 in dopamine neurons, braak

power
full sample -0.40 (p 0.103, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.042, n 18). not the mix.
skeptic
leave-one-out range -0.52 to -0.32, sign flips 0; without severely affected donors -0.40 (p 0.103, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for COTL1 in dopamine neurons.

case closed: nothing better to follow up.