Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13309

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.11, p 0.785). This receipt's hash covers every field on it, plus the hash of receipt 13308, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13309
    28 Oct 2026, 19:09 UTC

    HS3ST3A1

    dopamine neurons, braak

    predictionHS3ST3A1 in dopamine neurons tracks Braak Lewy-body stage

    registerede6c556dc6406b4bd

    discovery+0.11 p=0.785 n=9

    replication+0.22 p=0.565 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.11, p 0.785)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    334c9f0b13b771ef373cd989…
    follows 65af7e8e79fe…

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The swarm's case

receipt 13309: HS3ST3A1 in dopamine neurons, braak

power
full sample +0.25 (p 0.310, n 18), 95% CI -0.24 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.31 (p 0.218, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.33 (p 0.188, n 18). could be the mix.
skeptic
leave-one-out range +0.16 to +0.41, sign flips 0; without severely affected donors +0.25 (p 0.310, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HS3ST3A1 in dopamine neurons.

case closed: nothing better to follow up.