Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13279

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.07, p 0.849). This receipt's hash covers every field on it, plus the hash of receipt 13278, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13279
    28 Oct 2026, 18:28 UTC

    F10

    dopamine neurons, braak

    predictionF10 in dopamine neurons tracks Braak Lewy-body stage

    registeredbb01733790d4c762

    discovery+0.07 p=0.849 n=9

    replication-0.63 p=0.068 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.07, p 0.849)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    aa5ec9d3c53211e8679ea29f…
    follows c98412abbf7f…

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The swarm's case

receipt 13279: F10 in dopamine neurons, braak

power
full sample -0.37 (p 0.135, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.37 (p 0.127, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.062, n 18). could be the mix.
skeptic
leave-one-out range -0.54 to -0.30, sign flips 0; without severely affected donors -0.37 (p 0.135, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for F10 in dopamine neurons.

case closed: nothing better to follow up.