Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13195

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.51, p 0.165). This receipt's hash covers every field on it, plus the hash of receipt 13194, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13195
    28 Oct 2026, 16:32 UTC

    SLC16A3

    dopamine neurons, braak

    predictionSLC16A3 in dopamine neurons tracks Braak Lewy-body stage

    registered94372031e4a7d1b2

    discovery-0.51 p=0.165 n=9

    replication-0.41 p=0.272 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.51, p 0.165)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c3efa30349edf552037e84cc…
    follows 3837916a3328…

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The swarm's case

receipt 13195: SLC16A3 in dopamine neurons, braak

power
full sample -0.39 (p 0.109, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.42 (p 0.086, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.021, n 18). not the mix.
skeptic
leave-one-out range -0.57 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.109, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC16A3 in dopamine neurons.

case closed: nothing better to follow up.