Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13175

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.09, p 0.825). This receipt's hash covers every field on it, plus the hash of receipt 13174, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13175
    28 Oct 2026, 16:04 UTC

    SLC25A16

    dopamine neurons, braak

    predictionSLC25A16 in dopamine neurons tracks Braak Lewy-body stage

    registereddca27ad7c262c2dc

    discovery+0.09 p=0.825 n=9

    replication+0.10 p=0.802 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.09, p 0.825)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    9f34a92631c37f7a5a249795…
    follows 6d3fd0749d3b…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 13175: SLC25A16 in dopamine neurons, braak

power
full sample +0.12 (p 0.640, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.12 (p 0.640, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.476, n 18). could be the mix.
skeptic
leave-one-out range +0.01 to +0.25, sign flips 0; without severely affected donors +0.12 (p 0.640, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC25A16 in dopamine neurons.

case closed: nothing better to follow up.