Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12926

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.63, p 0.068). This receipt's hash covers every field on it, plus the hash of receipt 12925, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12926
    28 Oct 2026, 10:28 UTC

    IKBKE

    dopamine neurons, braak

    predictionIKBKE in dopamine neurons tracks Braak Lewy-body stage

    registered3d1100a316b56e1d

    discovery-0.63 p=0.068 n=9

    replication-0.45 p=0.227 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.63, p 0.068)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8b9732d52bd367c36adfc648…
    follows 17b15a25c881…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12926: IKBKE in dopamine neurons, braak

power
full sample -0.47 (p 0.050, n 18), 95% CI -0.77 to -0.00. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.50 (p 0.033, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.68 (p 0.0020, n 18). not the mix.
skeptic
leave-one-out range -0.56 to -0.40, sign flips 0; without severely affected donors -0.47 (p 0.050, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IKBKE in dopamine neurons.

case closed: nothing better to follow up.