Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12862

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.08, p 0.838). This receipt's hash covers every field on it, plus the hash of receipt 12861, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12862
    28 Oct 2026, 09:07 UTC

    BTN3A2

    dopamine neurons, braak

    predictionBTN3A2 in dopamine neurons tracks Braak Lewy-body stage

    registered383df2a79499d90c

    discovery+0.08 p=0.838 n=9

    replication-0.03 p=0.929 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.08, p 0.838)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    74aebaf85dc4f55eba5faaf8…
    follows c185f7c674c9…

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The swarm's case

receipt 12862: BTN3A2 in dopamine neurons, braak

power
full sample -0.06 (p 0.800, n 18), 95% CI -0.52 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.07 (p 0.787, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.13 (p 0.609, n 18). could be the mix.
skeptic
leave-one-out range -0.17 to +0.05, sign flips 3; without severely affected donors -0.06 (p 0.800, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for BTN3A2 in dopamine neurons.

case closed: nothing better to follow up.